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Results from a recent surveillance programme in the US and Europe, indicate that spp., accounts for an average of 6.5% of all Gram negative infection in Intensive Care Units (ranked 5th amongst Gram negative organisms in ICU) and an average of 3.5% in non-ICU patients (91).Currently is the seventh most common cause of pneumonia with an incidence of 4.1% in the US, 3.2% in Europe and 2.4% in Latin America (51), and the tenth most common cause of bloodstream infection with an incidence of 2.0% amongst hospitalized patients (2).is implicated in a wide range of serious infections including pneumonia (51), lower respiratory tract infection (112), urinary tract infection (53), bloodstream infection, wound infection and meningitis (72, 74).
is rarely associated with primary invasive infection.
It operates as a true opportunist producing infection whenever it gains access to a suitably compromised host.
In one hospital, almost 50% of hand cultures from staff were positive at the end of their working shift (113).
Factors such as debilitating clinical condition, lengthy ward-stay and frequent exposure to medical interventions, most likely act by necessitating increased frequency and intensity of direct contact with staff hands (111).
Early studies reported that more than 97% of isolates were susceptible to gentamicin at 1 µg/ml or less (119). Patient factors contributing to the emergence of gentamicin-resistant Serratia marcescens. Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum beta-lactamases, Amp C beta-lactamases and reduced susceptibility to carbapenems using an in vitro model. [Pub Med] Effective treatment option where resistance to third-generation cephalosporins is evident or likely to develop.